Quorum-sensing regulation of group behaviors in vibrios
Among the >600 genes controlled by quorum sensing through LuxR are genes required for type III secretion, type VI secretion, motility, and osmotic stress regulation. We are interested in the patterns of gene expression that control these important physiological outputs. LuxR, AphA, and the Qrrs are the central regulators of these expression patterns, though other downstream transcription factors also play important roles. Using bacterial genetics, bioinformatics, and biochemistry, we are examining the hierarchy of gene regulation that contributes to expression of key developmental and physiological pathways in vibrios. 
